An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)
The purpose of this study is to evaluate the safety and efficacy of mirikizumab inparticipants with moderately to severely active ulcerative colitis (UC) who have had aninadequate response to, loss of response, or who cannot tolerate conventional or biologic therapy for UC.
Trial Summary
Key Requirements
Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.Participants Must:
Participants must have a diagnosis of ulcerative colitis for at least 3 months before the planned start date for the study medications
Participants must have moderately or severely active ulcerative colitis at the start of the study
Participants must have had unsatisfactory results with or were unable to take other therapies for UC
Participants who are female must meet birth control requirements in order to participate in the study
Participants Must Not:
Participants must not have other types of inflammatory bowel disease, such as Crohn's disease or indeterminate colitis (also known as inflammatory bowel disease-unclassified)
Participants must not have had surgery in the past in order to remove part of the colon
Participants must not have certain complications of ulcerative colitis. One of these is called toxic megacolon. This is a condition where the colon is abnormally enlarged or dilated, often requiring surgical treatment
Participants must not have received certain types of medications for inflammatory diseases in the past. The study doctor can determine if you have received these when they speak with you at the screening visit
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Clinical Trial Resources
You will complete the questionnaire on another website.YesNo