Cancer Research
Lilly has been involved in cancer research for more than fifty years, working to improve the lives of people living with cancer. Learn more about cancer research at Lilly and how you can make an impact.
Learn MoreThis study is being conducted to test the safety and efficacy of ramucirumab in combination with other chemotherapy in the treatment of relapsed, recurrent, or refractory desmoplastic small round cell tumor (DSRCT) in children and young adults. This trial is part of the CAMPFIRE master protocol which is a platform to accelerate the development of new treatments for pediatric and young adult participants with cancer.
Participant must have relapsed, recurrent or refractory DSRCT
Participant must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 at time of enrollment
Participant must have received at least one line of prior systemic treatment at the time of enrollment
Participant must have adequate organ function, including blood, blood clotting, liver, kidney, heart and blood pressure control
Participant must not be a candidate for surgical tumor removal at the time of enrollment
Participant must not have already taken ramucirumab
Participant must not have previously progressed on the combined regimen of cyclophos/vinorelbine and must not have known allergies to any of the agents in the regimen
Participant must not be at risk for/have history of serious bleeding/blood clot events; heart problems; blood pressure crises/brain disease
Participant must not be at risk for/have history of stomach/liver problems; fistulas, ulcers, perforations, or abdominal abscesses; non-healing wounds or broken bones
Participant must not have urinary outflow obstruction, Grade 2 hematuria, or non-infectious cystitis at the time of enrollment
Lilly has been involved in cancer research for more than fifty years, working to improve the lives of people living with cancer. Learn more about cancer research at Lilly and how you can make an impact.
Learn MoreWith the help of research study participants, we are learning about pediatric conditions and potential new approaches to treating disease.
Learn MoreA clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.