Completed Enrollment

A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer (LIBRETTO-431)

J2G-MC-JZJC -

The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Non-small Cell Lung Cancer
What the trial is testing?
Carboplatin, Cisplatin, Pembrolizumab, Pemetrexed, Selpercatinib
Could I receive a Placebo?
No
Enrollment Goal
261
Trial Dates
Feb 17, 2020 - Jun 2026
How long will I be in the trial?
Your participation in this trial could last approximately 24 months, depending on your cancer type and how you and your tumor respond.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have advanced/metastatic non-squamous non-small cell lung cancer (NSCLC) that cannot be treated with surgery or radiation therapy

  • Participants must have a RET gene fusion and sufficient tumor tissue available for confirmatory testing

  • Participants must be in fair to good health and not Have another serious medical condition

  • Participants must not have had prior chemotherapy for metastatic lung cancer. chemotherapy in the adjuvant/neoadjuvant setting is permitted

  • Participants must not have disease that has spread to the brain and is causing symptoms

  • Participants must be able to swallow capsules

  • Participants must be willing to use highly effective contraception during the study

Participants Must Not:

  • Participants must not have a heart condition that puts you at risk for abnormal heart rhythms

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