Rheumatoid Arthritis Research
To learn more about rheumatoid arthritis and ongoing clinical trials in this area, visit our Rheumatoid Arthritis Research page.
Rheumatoid Arthritis ResearchThis post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous thromboembolic events (VTEs) when given to participants with rheumatoid arthritis (RA).
Participants must have at least one of the following characteristics: - Documented evidence of a VTE prior to this study - At least 60 years of age - A body mass index (BMI) greater than or equal to 30 kilograms per meter squared (kg/m²), or - Age 50 to less than 60 years and BMI 25 to less than 30 kg/m²
Participants must have an inadequate response or intolerance to at least 1 disease-modifying antirheumatic drugs (DMARD) (synthetic or biologic)
Participant must not have prior use of a Janus kinase (JAK) inhibitor or have received more than 1 prior TNF inhibitor that was: - Discontinued for IR (lack or loss of efficacy) for RA, or - Discontinued for intolerance (AE) when used for any indication
Participants must not be pregnant or breastfeeding
Participants must not have had more than one VTE
Participants must not have cancer
Participants must not have active herpes zoster, serious infection, active tuberculosis, or any other serious illness
Participants must not have had a live vaccine within four weeks of study start
Participants must not have participated in any other clinical trial within four weeks of study start
Participants must not have a history of IV drug use, other illicit drug abuse, or chronic alcohol abuse in the past year
To learn more about rheumatoid arthritis and ongoing clinical trials in this area, visit our Rheumatoid Arthritis Research page.
Rheumatoid Arthritis ResearchTo learn more about immune system conditions and ongoing clinical trials in this area, visit our Immunology Research page.
Learn MoreA clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.