Completed Enrollment

Study of LOXO-305 Versus Investigator's Choice (IdelaR or BR) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN CLL-321)

This is a study for participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have already received treatment. The main purpose is to compare pirtobrutinib to other drugs that have already been approved by the United States Food and Drug Administration (US FDA) for CLL/SLL.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
What the trial is testing?
Bendamustine, Idelalisib, LOXO-305, Rituximab
Could I receive a Placebo?
No
Enrollment Goal
250
Trial Dates
Mar 9, 2021 - May 2027
How long will I be in the trial?
Participation could last up to four years, and possibly longer, if the disease does not progress.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have chronic lymphocytic leukemia or small lymphocytic lymphoma that requires treatment

  • Have received prior treatment, including with a type of medicine called a BTK inhibitor

  • Be well enough to perform their own personal care

  • Have adequate organ function and blood counts, as measured by blood tests

Participants Must Not:

  • Have cancer that has become very aggressive or has spread to the brain or spinal cord

  • Have serious heart disease

  • Need a blood thinner called warfarin

  • Have any problems absorbing food or medicine taken by mouth

  • Take certain medicines that affect how fast the study drug is broken down in the body

  • Have active infection

Lilly Trial Alerts

Not the right fit? Sign up to receive updates about new trials that are listed or when a new trial site begins enrolling near you.

Clinical Trial Resources

Leukemia + Lymphoma Research

By volunteering to take part in Leukemia and Lymphoma clinical trials, you may be able to play an important role in the research and development of potential new treatments and medicines. We understand that when you or a loved one take part in a clinical trial, it is a big decision. It is important for you to understand why the research is being carried out and what taking part will mean for you. Learn more about Lilly

Leukemia + Lymphoma Research

Cancer Research

Lilly has been involved in cancer research for more than fifty years, working to improve the lives of people living with cancer. Learn more about cancer research at Lilly and how you can make an impact.

Learn More

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.