A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight for the Maintenance of Weight Loss (SURMOUNT-4)

I8F-MC-GPHN -

The main purpose is to learn more about how tirzepatide maintains body weight loss. The study has two phases: a lead-in phase in which all participants take tirzepatide and a treatment phase in which participants will either continue tirzepatide or switch to placebo.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Obesity
What the trial is testing?
Tirzepatide
Could I receive a Placebo?
Yes
Enrollment Goal
783
Trial Dates
Mar 29, 2021 - May 18, 2023
How long will I be in the trial?
The study will last about 94 weeks and may include up to 25 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have obesity or be overweight

  • Participants must be overweight and have high blood pressure, high cholesterol, sleep apnea or heart disease

  • Participants must agree to commit to and undergo study procedures as explained by clinic study staff

Participants Must Not:

  • Participants must not have diabetes

  • Participants must not have undergone weight loss surgery (e.g. stomach stapling, lap banding)

  • Participants must not have lost or gained weight in the last 3 months

  • Participants must not have chronic kidney disease

  • Participants must not have made prior suicide attempts

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Clinical Trial Resources

Weight Management Research

To learn more about obesity, overweight and ongoing clinical trials in the area, visit our Weight Management Research page. 

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.