Cardiovascular Research
To learn more about the types of cardiovascular disease and ongoing clinical trials we conduct in this area, visit our Cardiovascular Disease Research page.
Cardiovascular ResearchThe main purpose of this study is to determine the tolerability and safety of LY3461767 with any side effects that might be associated with it. Study drug will be provided in a continuous subcutaneous infusion lasting 24 hours to 96 hours, depending on the cohort. Blood tests will be performed to check concentrations of LY3461767 in the bloodstream and how long it takes the body to get rid of it in participants with chronic heart failure with reduced ejection fraction (HFrEF).
Participants must be males and in agreement to follow contraceptive requirements, or women of non-child-bearing potential
Participants must have a body mass index (BMI) of <= 45.0 kilograms per square meter (kg/m²)
Participants must have chronic stable heart failure (New York Heart Association (NYHA) classification II and III) on guideline directed heart failure therapy for at least 6 months prior to enrolment
Participants must have Left Ventricular Ejection Fraction (LVEF) < 40%
Participants must not have heart attack, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke in the last 90 days prior to screening
Participants must not have acute decompensated heart failure requiring IV diuretics within 12 weeks prior to screening
Participants must not have cardiac amyloidosis, accumulation diseases (e.g., haemochromatosis, Fabry disease), muscular dystrophies, hypertrophic cardiomyopathy, pericardial constriction, or complex congenital heart disease
Participants must not have a history or presence of hepatic, pancreatic, or biliary tract disorders
Participants must not have a history of malignancy or active malignancy at screening
To learn more about the types of cardiovascular disease and ongoing clinical trials we conduct in this area, visit our Cardiovascular Disease Research page.
Cardiovascular ResearchA clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.