A Study of Tirzepatide in Overweight and Very Overweight Participants

I8F-MC-GPHH -

The main purpose of this study is to measure the effect of tirzepatide on food intake in participants who are overweight or very overweight. The study will also use imaging to learn more about how tirzepatide affects specific parts of the brain. The effect of tirzepatide on appetite will also be studied.

Trial Summary

Age Range
18 - 65 years
Conditions the trial is for
Obesity
What the trial is testing?
Tirzepatide, Placebo, Liraglutide
Could I receive a Placebo?
Yes
Enrollment Goal
114
Trial Dates
Aug 24, 2020 - Dec 16, 2022
How long will I be in the trial?
The study will last up to about four months and will include up to 14 visits to the study center.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must be overweight or very overweight

  • Participants must have stable body weight over the last month

  • Participants must agree to commit to and undergo study procedures as explained by clinic study staff

Participants Must Not:

  • Participants must not have undergone weight loss surgery (e.g. stomach stapling, lapbanding)

  • Participants must not have been diagnosed as having diabetes

  • Participants must not have used or intend to use weight loss drugs

  • Participant must not have magnetic implants or suffer from a fear of being in an enclosed space

  • Female participants must not be pregnant or breastfeeding

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Clinical Trial Resources

Weight Management Research

To learn more about obesity, overweight and ongoing clinical trials in the area, visit our Weight Management Research page. 

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.