Enrolling

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (BRUIN CLL-322)

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This is a study for participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have already received treatment for this disease. The main purpose is to add pirtobrutinib to other drugs that have already been approved by the United States Food and Drug Administration (US FDA), and by many other countries, for CLL/SLL.

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See if You May Qualify

Answer a few questions to see if you meet key criteria for this study.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
What the trial is testing?
Pirtobrutinib, Rituximab, Venetoclax
Could I receive a Placebo?
No
Enrollment Goal
600
Trial Dates
Sep 20, 2021 - Jan 2027
How long will I be in the trial?
Participation could last up to five years, and possibly longer, if the disease does not get worse.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have chronic lymphocytic leukemia or small lymphocytic lymphoma that requires treatment

  • Have already had treatment for this disease

  • Be well enough to perform their own personal care

  • Have adequate organ function and blood counts, as measured by blood tests

Participants Must Not:

  • Have cancer that has changed to different type of cancer or has spread to the brain or spinal cord

  • Have serious heart disease

  • Need a blood thinner called warfarin

  • Have any problems absorbing food or medicine taken by mouth

  • Take certain medicines that affect how fast the study drug is broken down in the body

  • Have active infection

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Clinical Trial Resources

Leukeima + Lymphoma Research

To learn more about leukemia and lymphoma and ongoing clinical trials in this area, visit our Leukemia + Lymphoma Research page.

Leukemia + Lymphoma Research

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.