The main purpose of this study is to determine the efficacy and safety of LY3819469 in adults with elevated lipoprotein (a).
Participants must be at least 40 years old and have Lp(a) level≥175 nmol/L at screening
Participants if on lipid-lowering drugs or hormone therapy need to be on stable dose for at least 4 weeks prior to screening
A body mass index within the range 18.5 to 40 kilogram/square meter
Males who agree to use highly effective contraception methods or women not of childbearing age
Have a history or presence of an underlying disease, or surgical, physical, medical, or psychiatric condition that in the opinion of the investigator, would affect participant safety within the study or interfere with participating in or completing the study or with the interpretation of data.
Had major surgery within 3 months of day 1
Had coronary, carotid, or peripheral arteria revascularization, stroke, heart attack or chest pain within 3 months of day 1
Have uncontrolled diabetes
Have uncontrolled high blood pressure
Women of childbearing potential
By volunteering to take part in Cardiovascular clinical trials, you may be able to play an important role in the research and development of potential new treatments and medicines. We understand that when you or a loved one take part in a clinical trial, it is a big decision. It is important for you to understand why the research is being carried out and what taking part will mean for you. Learn more about Lilly
Cardiovascular Research
A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.