Cardiovascular Research
To learn more about the types of cardiovascular disease and ongoing clinical trials we conduct in this area, visit our Cardiovascular Disease Research page.
Cardiovascular ResearchThe main purpose of this study is to determine the tolerability and side effects related to LY3875383 given as a single injection under the skin to healthy participants and participants with elevated triglyceride (TG) levels. The study will also assess how fast LY3875383 gets into the blood stream and how long the body takes to get rid of it. Each enrolled participant will receive a single dose of either LY3875383 or placebo[SR1] .
All participants:
Have a body mass index (BMI) ranging from 18.0 to 40.0 kilograms per meter squared (kg/m2)
Male participants must agree to use birth control and female participants not of childbearing potential
Healthy participants (Part A):
Participants must be overtly healthy, as determined by medical evaluation
Hypertriglyceridemia participants (Parts B, C and D):
For Part B : Participants must be first-generation Japanese, defined as the participant’s biological parents, and all of the participant’s biological grandparents must be of exclusive Japanese descent and born in Japan
For Part C : Have history of very high triglyceride (lipid) level 500 mg/dL ≤ TG <2000 mg/dL
For Part D : Have a history of high triglyceride (lipid) level between 150mg/dL and 500 mg/dL inclusive
Be currently participating in or completed a clinical trial within the last 30 days
Have donated blood of more than 500 mL within the previous 3 months
Have been tested positive for human immunodeficiency virus (HIV) or hepatitis B or C
Be heavy alcohol drinkers or cigarette smokers.
For Part C: Participants must not have inflammation of the pancreas
To learn more about the types of cardiovascular disease and ongoing clinical trials we conduct in this area, visit our Cardiovascular Disease Research page.
Cardiovascular ResearchA clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.