Enrolling
A Study of LOXO-435 in Participants With Cancer With a Change in a Gene Called FGFR3
J4G-OX-JZVA - ClinicalTrials.gov - NCT05614739
The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435.
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Trial Summary
Age Range
≥18 yearsConditions the trial is for
Bladder Cancer, Advanced Solid TumorsWhat the trial is testing?
LOX-24350 / LOXO-435, PembrolizumabCould I receive a Placebo?
NoEnrollment Goal
180Trial Dates
Jan 12, 2023 - Jun 2025How long will I be in the trial?
Your participation in this trial could last up to 30 months (2.5 years) and possibly longer if the disease does not get worse.Trial Phase
IKey Requirements
Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.Participants Must:
Have solid tumor cancer with a change in the FGFR3 gene
Cancer must be advanced or has spread to another part(s) of the body
Have stopped all cancer treatment and have recovered from the major side effects
Have blood test results that show that organs are working adequately
Participants Must Not:
Have a serious disorder of the eye
Have an active infection
Have cancer that began in the brain or spread to the brain and is causing symptoms
Have a serious heart condition
Patients who are pregnant, lactating, or plan to breastfeed during the study or within 6 months of the last dose of study treatment
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Clinical Trial Resources
You will complete the questionnaire on another website.YesNo