A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 In Participants With Osteoarthritis Pain (OA05)

H0P-MC-OA05 -

The main purpose of this study is to evaluate the efficacy and safety of LY3857210 in participants with osteoarthritic pain. This trial is part of the chronic pain master protocol (H0P-MC-CPMP) which is a protocol to accelerate the development of new treatments for chronic pain.

Trial Summary

Age Range
≥40 years
Conditions the trial is for
Osteoarthritis Pain, Chronic Pain
What the trial is testing?
LY3852710
Could I receive a Placebo?
Yes
Enrollment Goal
147
Trial Dates
Nov 22, 2022 - Jun 12, 2023
How long will I be in the trial?
The study will last about 12 weeks and may include up to 8 visits.
Trial Phase
II

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have a history of daily pain for at least 12 weeks

  • Participants must be willing to maintain any non-drug pain relieving therapies (for example, physical therapy) and not start any new non-drug pain-relieving therapies during the study

  • Are willing to discontinue all medications taken for chronic pain conditions throughout the study

  • Have knew pain for >12 weeks at screening

Participants Must Not:

  • Have a siezure disorder or history of seizure

  • Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to starting the washout period

  • Have presence of surgical hardware or other foreign body in the index knee.

  • Have a surgery planned during the study for any reason

  • Have had cancer within 2 years of baseline

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.