A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Chronic Low Back Pain

H0P-MC-BP05 -

The main purpose of this study is to assess whether LY3857210 is safe and efficacious in relieving chronic low back pain (CLBP).

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Chronic Low-back Pain
What the trial is testing?
LY3857210
Could I receive a Placebo?
Yes
Enrollment Goal
138
Trial Dates
Dec 8, 2022 - Jun 15, 2023
How long will I be in the trial?
The study will last about 12 weeks and may include up to 8 visits.
Trial Phase
II

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must be willing to maintain any non-drug pain relieving therapies (for example, physical therapy) and not start any new non-drug pain-relieving therapies during the study

  • Participants must be willing to stop all pain medications for lower back pain, except for rescue medication allowed in the study

  • Participants must have a history daily pain for at least 12 weeks

Participants Must Not:

  • Have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest.

  • Have surgery planned during the study for any reason

  • Have had cancer within 2 years, except for certain types of skin cancer (cutaneous basal cell or squamous cell carcinoma) surgically removed

  • Have an intolerance to acetaminophen or paracetamol

  • Have had a major recent trauma within 6 months of start of study intervention

  • Have a seizure disorder or history of seizure

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Clinical Trial Resources

Pain Research

To learn more about clinical trials for pain, visit our Pain Research page. 

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.