Enrolling

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk (ACHIEVE-4)

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 Diabetes, Overweight at Increased Cardiovascular Risk
What the trial is testing?
Orforglipron (LY3502970), Insulin Glargine
Could I receive a Placebo?
No
Enrollment Goal
2620
Trial Dates
Apr 3, 2023 - Dec 2025
How long will I be in the trial?
The study will last approximately 2 years may include up to 27 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have type 2 diabetes

  • Be taking a consistent dose of 1 to 3 diabetes drugs by mouth for the last 3 months

  • Be at high risk of heart or blood vessel diseases, or have kidney disease

  • Have high blood sugar as measured by hemoglobin A1C (HbA1c at least 7%)

Participants Must Not:

  • Have type 1 diabetes

  • Have history of an inflamed pancreas (pancreatitis)

  • Have history of an inflamed liver (hepatitis)

  • Have used any weight loss drugs, including herbal or nutritional supplements, within the last 3 months

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Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.