Enrolling
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk (ACHIEVE-4)
J2A-MC-GZGS - ClinicalTrials.gov - NCT05803421
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk.
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Trial Summary
Age Range
≥18 yearsConditions the trial is for
Type 2 Diabetes, Overweight at Increased Cardiovascular RiskWhat the trial is testing?
Orforglipron (LY3502970), Insulin GlargineCould I receive a Placebo?
NoEnrollment Goal
2620Trial Dates
Apr 3, 2023 - Dec 2025How long will I be in the trial?
The study will last approximately 2 years may include up to 27 visits.Trial Phase
IIIKey Requirements
Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.Participants Must:
Have type 2 diabetes
Be taking a consistent dose of 1 to 3 diabetes drugs by mouth for the last 3 months
Be at high risk of heart or blood vessel diseases, or have kidney disease
Have high blood sugar as measured by hemoglobin A1C (HbA1c at least 7%)
Participants Must Not:
Have type 1 diabetes
Have history of an inflamed pancreas (pancreatitis)
Have history of an inflamed liver (hepatitis)
Have used any weight loss drugs, including herbal or nutritional supplements, within the last 3 months
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Clinical Trial Resources
You will complete the questionnaire on another website.YesNo