Completed Enrollment

A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities (SURMOUNT-5)

The main purpose of this phase 3b study is to evaluate the efficacy and safety of tirzepatide compared with semaglutide in adult participants who have obesity or overweight with weight related comorbidities without type 2 diabetes.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Overweight, Obesity
What the trial is testing?
Tirzepatide, Semaglutide
Could I receive a Placebo?
No
Enrollment Goal
700
Trial Dates
Apr 21, 2023 - Nov 2024
How long will I be in the trial?
The study will last about 78 weeks and may include up to 21 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have obesity

  • Have overweight with at least one:

    • obstructive sleep apnea

    • Have high blood pressure

    • Have high cholesterol

    • Have heart disease

Participants Must Not:

  • Have type 1 or type 2 diabetes

  • Have a self-reported change in body weight over 5 kg within 3 months before screening

  • Have a planned or prior surgery for obesity

  • Have “severe” kidney impairment

  • Have long-term or short- term inflammation of the pancreas

Lilly Trial Alerts

Not the right fit? Sign up to receive updates about new trials that are listed or when a new trial site begins enrolling near you.

Clinical Trial Resources

Obesity Research

Click the below button to learn more about obesity research and clinical trials.

Learn More

Driving Diversity in Lilly’s clinical trials

Learn how Lilly is working with health care partners to improve diversity in our clinical studies.

Watch the Video

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.