The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD).
Have excess weight
Have heart attack, stroke, or peripheral arterial disease
Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight
Have had the following within 90 days before screening: heart attack, stroke, hospitalization for congestive heart failure or unstable angina
Have been taking any weight loss drugs, including over-the-counter medications, within 90 days before screening
Have had a change in body weight greater than 11 pounds within 90 days
Have or are planning a surgical treatment for excess weight
Have Type 1 diabetes
Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
Have had pancreatitis
By volunteering to take part in Cardiovascular clinical trials, you may be able to play an important role in the research and development of potential new treatments and medicines. We understand that when you or a loved one take part in a clinical trial, it is a big decision. It is important for you to understand why the research is being carried out and what taking part will mean for you. Learn more about Lilly
Cardiovascular Research
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Learn how Lilly is working with health care partners to improve diversity in our clinical studies.
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A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.