Enrolling

A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3)

The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD).

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Obesity, Overweight and Cardiovascular Disease
What the trial is testing?
Retatrutide
Could I receive a Placebo?
Yes
Enrollment Goal
1800
Trial Dates
May 30, 2023 - Feb 2026
How long will I be in the trial?
The study will last about 113 weeks and may include up to approximately 30 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have excess weight

  • Have heart attack, stroke, or peripheral arterial disease

  • Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight

Participants Must Not:

  • Have had the following within 90 days before screening: heart attack, stroke, hospitalization for congestive heart failure or unstable angina

  • Have been taking any weight loss drugs, including over-the-counter medications, within 90 days before screening

  • Have had a change in body weight greater than 11 pounds within 90 days

  • Have or are planning a surgical treatment for excess weight

  • Have Type 1 diabetes

  • Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) 

  • Have had pancreatitis

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Clinical Trial Resources

Cardiovascular (Heart Disease) Research

By volunteering to take part in Cardiovascular clinical trials, you may be able to play an important role in the research and development of potential new treatments and medicines. We understand that when you or a loved one take part in a clinical trial, it is a big decision. It is important for you to understand why the research is being carried out and what taking part will mean for you. Learn more about Lilly

Cardiovascular Research

Obesity Research

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Driving Diversity in Lilly’s clinical trials

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Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.