A Study of LY3532226 in Participants With Type 1 Diabetes Mellitus

J2V-MC-GZLC -

The main purpose of this study is to evaluate the response of glucagon to insulin-induced low blood sugar after administration of the study drug LY3532226 in participants with type 1 diabetes mellitus (T1DM). The study will also evaluate if LY3532226 helped participants to recover from insulin-induced low blood sugar condition compared to placebo.

Trial Summary

Age Range
18 - 70 years
Conditions the trial is for
Type 1 Diabetes
What the trial is testing?
LY3532226
Could I receive a Placebo?
Yes
Enrollment Goal
30
Trial Dates
Jun 12, 2023 - Feb 21, 2024
How long will I be in the trial?
Your participation could last about 20 weeks and may include up to 08 visits to the study center
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants with type 1 diabetes mellitus (T1DM) for at least 2 years treated with insulin

  • Participants with body mass index (BMI) of 18.5 to 40.0 kilograms per meter squared (kg/m²)

  • Are males or females not of childbearing potential

Participants Must Not:

  • Participants with acute proliferative retinopathy requiring active treatment within 3 months of screening

  • Participants who have been treated with dipeptidyl peptidase-Ni, GLP-1 receptor agonists, GIP agonists, metformin or sodium-glucose cotransporter 2 inhibitors within the previous 3 months

  • Participants who received systemic or inhaled glucocorticoid therapy

  • Women of childbearing potential 

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Clinical Trial Resources

Diabetes Research

To learn more about diabetes and ongoing clinical trials in this area, visit our Diabetes Research page.

Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.