A Study of LY3502970 in Participants With Impaired and Normal Liver Function
The main purpose of this study is to measure how much of LY3502970 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to participants with normal liver function. The safety and tolerability of LY3502970 will also be evaluated.
Trial Summary
Key Requirements
Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.Participants Must:
Be Men or women with body weight of at least 45 kilograms and a body mass index of 18.5 to 40.0 kilograms per meter squared (kg/m²)
Participants must have a diagnosis of chronic hepatic impairment for more than 6 months per physician diagnosis
Participants with acceptable BP and pulse rate
Participants with no significant history of spontaneous or ethanol induced hypoglycemia
Have T2DM controlled with diet or exercise alone or on stable doses of anti-diabetic medication metformin or sulfonylureas, for at least 8 weeks prior to screening
Participants with Mild to Severe Hepatic Impairment who have a hemoglobin level of at least 8.5 grams/decilitre
Participants with both T2DM and Hepatic Impairment have a hemoglobin A1c greater than or equal to 5.0% and less than or equal to 11.0% at the screening visit
Participants with both T2DM and Hepatic Impairment have clinical laboratory test results within normal range
Participants Must Not:
Participants with any abnormality in the 12-lead ECG at screening
Participants with severe atopy or have a history of clinically significant multiple or severe drug allergies or severe post treatment hypersensitivity reactions
Have a history of, or current psychiatric disorders
Women who are pregnant, intend to become pregnant or are breastfeeding a child are not eligible to participate
Have taken any glucose-lowering medications other than metformin, sulfonylureas, and insulin, in the past 6 weeks or 5 half-lives (whichever is longer) prior to planned dosing
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Clinical Trial Resources
You will complete the questionnaire on another website.YesNo