Enrolling

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight (TRIUMPH-1)

J1I-MC-GZBJ -

The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1).

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Obesity, Overweight, Osteoarthritis, Sleep Apnea
What the trial is testing?
Retatrutide
Could I receive a Placebo?
Yes
Enrollment Goal
2100
Trial Dates
Jul 10, 2023 - May 2026
How long will I be in the trial?
The study will last about 89 weeks and include up to 24 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have excess weight

  • Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight

Participants Must Not:

  • Have a self-reported or documented change in body weight >11 pounds within 90 days before screening

  • Have taken weight loss drugs, including over-the-counter medications, within 90 days before screening

  • Have a prior or planned surgical treatment for obesity

  • Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes

  • Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)

  • Have had pancreatitis

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Clinical Trial Resources

Weight Management Research

To learn more about obesity, overweight and ongoing clinical trials in the area, visit our Weight Management Research page. 

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.