Enrolling

A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee (TRIUMPH-4)

J1I-MC-GZBN -

The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants who have obesity or are overweight and have osteoarthritis of the knee.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Obesity, Overweight and Osteoarthritis of the Knee
What the trial is testing?
Retatrutide
Could I receive a Placebo?
Yes
Enrollment Goal
405
Trial Dates
Aug 1, 2023 - Mar 2026
How long will I be in the trial?
The study will last about 77 weeks and may include up to 23 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have excess weight

  • Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight

Participants Must Not:

  • Have had a change in body weight greater than 11 pounds within 90 days

  • Have prior joint replacement in the index knee

  • Have had injections or other procedures for knee pain within 6 months

  • Have joint disease in the index knee other than osteoarthritis

  • Have taken weight loss drugs within 90 days

  • Have or are planning a surgical treatment for excess weight

  • Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes

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