Enrolling

A Study of Orforglipron (LY3502970) in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (ACHIEVE-1)

J2A-MC-GZGT -

The main purpose of this study is to determine safety and efficacy of orforglipron compared with placebo in adult participants with type 2 diabetes and inadequate glycemic control with diet and exercise alone.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 Diabetes
What the trial is testing?
Orforglipron
Could I receive a Placebo?
Yes
Enrollment Goal
520
Trial Dates
Aug 9, 2023 - Apr 2025
How long will I be in the trial?
The study will last about 54 weeks and may include up to 13 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have Type 2 Diabetes

  • Are naïve to insulin therapy

  • Are on stable weight for at least 90 days prior to screening

  • Be overweight

Participants Must Not:

  • Have Type 1 Diabetes

  • Have Congestive heart failure

  • Have acute or chronic pancreatitis

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Clinical Trial Resources

Diabetes Research

To learn more about diabetes and clinical trials being carried out in this area, visit our Diabetes Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.