A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor (ACHIEVE-5)

The main purpose of this study is to determine the safety and efficacy of orforglipron. Participants will have Type 2 Diabetes (T2D) and have inadequate glycemic control with insulin glargine with or without metformin and/or SGLT-2 (sodium-glucose cotransporter-2) inhibitor.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 Diabetes
What the trial is testing?
Could I receive a Placebo?
Enrollment Goal
Trial Dates
Nov 10, 2023 - Jun 2025
How long will I be in the trial?
The study will last about 46 weeks and may include up to 20 visits.
Trial Phase

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have Type 2 Diabetes

  • Be taking a consistent dose of diabetes drug by injection for at least 3 months

  • May be taking up to 2 diabetes drugs by mouth for at least 3 months

  • Have a high blood sugar

Participants Must Not:

  • Have Type 1 diabetes

  • Have history of an inflamed pancreas (pancreatitis)

  • Have history of an inflamed liver (hepatitis)

  • Have congestive heart failure

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Take the Next Step

Complete this Lilly Trial Match questionnaire to find out if this clinical trial may be a good fit for you, or a loved one.
When you press Start Lilly Trial Match, you will answer questions about relevant medical conditions and treatment history. The answers will be compared to some of the key criteria for this trial, called inclusion and exclusion criteria.

If your responses show that the trial may be a good fit, you can:
  • Select which clinical trial site works best for you.
  • Share your details and questionnaire directly with site(s) that allow this.
  • Get contact details for the site(s) of your choice.

Completing the Trial Match questionnaire doesn’t mean that you will be enrolled in a study. There may be more eligibility criteria for the study which are assessed by the Lilly clinical team.

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