Enrolling

A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor (ACHIEVE-5)

J2A-MC-GZGW -

The main purpose of this study is to determine the safety and efficacy of orforglipron. Participants will have Type 2 Diabetes (T2D) and have inadequate glycemic control with insulin glargine with or without metformin and/or SGLT-2 (sodium-glucose cotransporter-2) inhibitor.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 Diabetes
What the trial is testing?
Orforglipron
Could I receive a Placebo?
Yes
Enrollment Goal
520
Trial Dates
Nov 10, 2023 - Jun 2025
How long will I be in the trial?
The study will last about 46 weeks and may include up to 20 visits.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have Type 2 Diabetes

  • Be taking a consistent dose of diabetes drug by injection for at least 3 months

  • May be taking up to 2 diabetes drugs by mouth for at least 3 months

  • Have a high blood sugar

Participants Must Not:

  • Have Type 1 diabetes

  • Have history of an inflamed pancreas (pancreatitis)

  • Have history of an inflamed liver (hepatitis)

  • Have congestive heart failure

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Clinical Trial Resources

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Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.