A Study to Investigate the Safety and Tolerability of LY3938577 in Healthy Participants and Participants With Type 2 Diabetes Mellitus

The main purpose of this study is to assess the safety and tolerability of a single dose of LY3938577 in healthy participants and participants with Type 2 Diabetes Mellitus (T2DM) (Part A) and multiple doses of LY3938577 in participants with T2DM (Part B).

Enter your city or zip code to find the nearest site

See if You May Qualify

Answer a few questions to see if you meet key criteria for this study.

Trial Summary

Age Range
18 - 70 years
Conditions the trial is for
Type 2 diabetes, Healthy volunteers
What the trial is testing?
LY3938577, insulin degludec
Could I receive a Placebo?
Enrollment Goal
Trial Dates
Nov 17, 2023 - Aug 2024
How long will I be in the trial?
The study will last approximately 6 weeks for Part A and approximately 10 weeks for Part B respectively
Trial Phase

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Healthy participants determined by medical evaluation

  • Have Type 2 Diabetes for at least 1 year prior to screening

  • Have Stable Body Weight for at least 90 days prior to screening

Participants Must Not:

  • Have proliferative retinopathy or maculopathy

  • Have received systemic glucocorticoid therapy

  • Have a history of heart disease or other heart conditions like heart failure, cerebrovascular stroke

  • Have been taking weight loss drugs, including over-the-counter medications within 6 months prior to screening

Lilly Trial Alerts

Not the right fit? Sign up to receive updates about new trials that are listed or when a new trial site begins enrolling near you.

Take the Next Step

Complete this Lilly Trial Match questionnaire to find out if this clinical trial may be a good fit for you, or a loved one.
When you press Start Lilly Trial Match, you will answer questions about relevant medical conditions and treatment history. The answers will be compared to some of the key criteria for this trial, called inclusion and exclusion criteria.

If your responses show that the trial may be a good fit, you can:
  • Select which clinical trial site works best for you.
  • Share your details and questionnaire directly with site(s) that allow this.
  • Get contact details for the site(s) of your choice.

Completing the Trial Match questionnaire doesn’t mean that you will be enrolled in a study. There may be more eligibility criteria for the study which are assessed by the Lilly clinical team.

Clinical Trial Resources

Diabetes Research

To learn more about diabetes and clinical trials being carried out in this area, visit our Diabetes Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.