A Study to Investigate the Safety and Tolerability of LY3938577 in Healthy Participants and Participants With Type 2 Diabetes Mellitus

J4P-MC-IYAA -

The main purpose of this study is to assess the safety and tolerability of a single dose of LY3938577 in healthy participants and participants with Type 2 Diabetes Mellitus (T2DM) (Part A) and multiple doses of LY3938577 in participants with T2DM (Part B).

Trial Summary

Age Range
18 - 70 years
Conditions the trial is for
Type 2 diabetes, Healthy volunteers
What the trial is testing?
LY3938577, insulin degludec
Could I receive a Placebo?
Yes
Enrollment Goal
66
Trial Dates
Nov 17, 2023 - Jun 28, 2024
How long will I be in the trial?
The study will last approximately 6 weeks for Part A and approximately 10 weeks for Part B respectively
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Healthy participants determined by medical evaluation

  • Have Type 2 Diabetes for at least 1 year prior to screening

  • Have Stable Body Weight for at least 90 days prior to screening

Participants Must Not:

  • Have proliferative retinopathy or maculopathy

  • Have received systemic glucocorticoid therapy

  • Have a history of heart disease or other heart conditions like heart failure, cerebrovascular stroke

  • Have been taking weight loss drugs, including over-the-counter medications within 6 months prior to screening

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Clinical Trial Resources

Diabetes Research

To learn more about diabetes and ongoing clinical trials in this area, visit our Diabetes Research page.

Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.