A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (ACHIEVE-2)

The main purpose of this study is to assess the safety and efficacy of orforglipron compared with dapagliflozin in improving blood sugar control in participants with type 2 diabetes (T2D) with inadequate glycemic control using metformin.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 diabetes
What the trial is testing?
dapagliflozin, orforglipron
Could I receive a Placebo?
Enrollment Goal
Trial Dates
Jan 11, 2024 - Oct 2025
How long will I be in the trial?
The study will last approximately 46 weeks.
Trial Phase

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have Type 2 diabetes

  • Have been on stable diabetes treatment with metformin 90 days before study start through randomization

  • Have not lost or gained body weight for at least 90 days prior to baseline and agree to not start an intensive diet or exercise program during the study with the intent to lose body weight other than lifestyle and/or dietary measures for diabetes treatment

Participants Must Not:

  • Have Type 1 Diabetes

  • Have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6 months prior to baseline

  • Have had congestive heart failure

  • Have had heart attack, stroke or hospitalized for congestive heart failure

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Take the Next Step

Complete this Lilly Trial Match questionnaire to find out if this clinical trial may be a good fit for you, or a loved one.
When you press Start Lilly Trial Match, you will answer questions about relevant medical conditions and treatment history. The answers will be compared to some of the key criteria for this trial, called inclusion and exclusion criteria.

If your responses show that the trial may be a good fit, you can:
  • Select which clinical trial site works best for you.
  • Share your details and questionnaire directly with site(s) that allow this.
  • Get contact details for the site(s) of your choice.

Completing the Trial Match questionnaire doesn’t mean that you will be enrolled in a study. There may be more eligibility criteria for the study which are assessed by the Lilly clinical team.

Clinical Trial Resources

Diabetes Research

To learn more about diabetes and clinical trials being carried out in this area, visit our Diabetes Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.