Enrolling

A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (ACHIEVE-2)

J2A-MC-GZGV -

The main purpose of this study is to assess the safety and efficacy of orforglipron compared with dapagliflozin in improving blood sugar control in participants with type 2 diabetes (T2D) with inadequate glycemic control using metformin.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 diabetes
What the trial is testing?
dapagliflozin, orforglipron
Could I receive a Placebo?
No
Enrollment Goal
888
Trial Dates
Jan 10, 2024 - Oct 2025
How long will I be in the trial?
The study will last approximately 46 weeks.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have Type 2 diabetes

  • Have been on stable diabetes treatment with metformin 90 days before study start through randomization

  • Have not lost or gained body weight for at least 90 days prior to baseline and agree to not start an intensive diet or exercise program during the study with the intent to lose body weight other than lifestyle and/or dietary measures for diabetes treatment

Participants Must Not:

  • Have Type 1 Diabetes

  • Have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6 months prior to baseline

  • Have had congestive heart failure

  • Have had heart attack, stroke or hospitalized for congestive heart failure

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.