Enrolling

A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Solid tumors
What the trial is testing?
LY4101174
Could I receive a Placebo?
No
Enrollment Goal
280
Trial Dates
Mar 5, 2024 - Mar 2027
How long will I be in the trial?
The study will last up to approximately 4 years
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have one of the following solid tumor cancers:

    urothelial cancer, triple negative breast cancer, non-small cell lung cancer, esophageal cancer, pancreatic cancer, ovarian cancer, cervical cancer (squamous cell cancer), head and neck squamous cell cancer or prostate cancer

  • Have stopped all cancer treatment and have recovered from the major side effects

  • Have blood test results that show that organs are working adequately

Participants Must Not:

  • Have cancer that spread to the brain and is causing symptoms

  • Have uncontrolled increase in serum calcium levels

  • Have serious disorder of the eye

  • Have serious heart condition, or lung disease

  • Have serious skin toxicity when receiving enfortumab vedotin

  • Be pregnant, breastfeeding or plan to breastfeed during study or within 30 days of last dose of study intervention

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