Not Yet Enrolling

A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)

J4P-MC-IYAB -

The main purpose of this study is to look at the amount of the study drug LY3938577 that gets into the blood stream and how long it takes the body to get rid of it.

Trial Summary

Age Range
18 - 64 years
Conditions the trial is for
Type 1 diabetes, Healthy volunteers
What the trial is testing?
LY3938577, insulin degludec, insulin lispro
Could I receive a Placebo?
Yes
Enrollment Goal
70
Trial Dates
May 2024 - Feb 2025
How long will I be in the trial?
The study will last up to approximately 5.5, 10 and 13 weeks for parts A, B, and C, respectively, including screening period.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants with body mass index (BMI) of 18.5 to 35.0 kilograms per meter squared (kg/m²)

  • Must be males or females not of childbearing potential

  • Part B and C - Participants with type 1 diabetes mellitus (T1DM) for at least 2 years treated with insulin

Participants Must Not:

  • Participants must not have had heart disease or other heart conditions like heart attack, heart failure or stroke

Part B and C -

  • Have had more than 1 emergency treatment or hospitalization for very low blood sugar or very high blood sugar level in the past 6 months

  • Have been treated with Glucagon-like Peptide-1 Receptor Agonists (GLP1-RA), Dipeptidyl Peptidase 4 (DPP4) inhibitor, Glucose-dependent Insulinotropic Polypeptide (GIP) agonists, Metformin, or Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors within the previous 3 months

  • Participants who received systemic or inhaled glucocorticoid therapy

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