Cardiovascular Research
To learn more about the types of cardiovascular disease and ongoing clinical trials we conduct in this area, visit our Cardiovascular Disease Research page.
Cardiovascular ResearchThe purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin).
Have high lipoprotein(a) level, at least 175 nmol/L, and either:
Be at least 18 years old and have had a cardiac event (like a heart attack or cardiac bypass surgery), a stroke, or peripheral arterial event (like a stent in an artery in the leg or an amputation)
Or
Be at least 55 years old and have risk factors for a cardiac event, like narrowing of the coronary or carotid arteries; a condition called familial hypercholesterolemia; or a group of other risk factors for cardiovascular disease
Have had major surgery, cardiac event, or stroke within 90 days of day 1
Have very high blood pressure
Have kidney failure that requires dialysis
Have chronic liver problems
Have cancer
To learn more about the types of cardiovascular disease and ongoing clinical trials we conduct in this area, visit our Cardiovascular Disease Research page.
Cardiovascular ResearchA clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.