Enrolling

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin).

Group of people

See if You May Qualify

Answer a few questions to see if you meet key criteria for this study.
Speak to a study nurse at 1-844-901-0340 or

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Atherosclerotic cardiovascular disease, Elevated Lp(a)
What the trial is testing?
Lepodisiran
Could I receive a Placebo?
Yes
Enrollment Goal
12500
Trial Dates
Mar 5, 2024 - Mar 2029
How long will I be in the trial?
The study is likely to last 4-5yrs. It will continue until all the study information has been collected.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have high lipoprotein(a) level, at least 175 nmol/L, and either:

    • Be at least 18 years old and have had a cardiac event (like a heart attack or cardiac bypass surgery), a stroke, or peripheral arterial event (like a stent in an artery in the leg or an amputation)

    Or

    • Be at least 55 years old and have risk factors for a cardiac event, like narrowing of the coronary or carotid arteries; a condition called familial hypercholesterolemia; or a group of other risk factors for cardiovascular disease

Participants Must Not:

  • Have had major surgery, cardiac event, or stroke within 90 days of day 1

  • Have very high blood pressure

  • Have kidney failure that requires dialysis

  • Have chronic liver problems

  • Have cancer

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Clinical Trial Resources

Cardiovascular (Heart Disease) Research

By volunteering to take part in Cardiovascular clinical trials, you may be able to play an important role in the research and development of potential new treatments and medicines. We understand that when you or a loved one take part in a clinical trial, it is a big decision. It is important for you to understand why the research is being carried out and what taking part will mean for you. Learn more about Lilly

Cardiovascular Research

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.