Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and renal impairment, with inadequate glycemic control on basal insulin alone or a combination of basal insulin with or without metformin and/or sodium-glucose cotransporter-2 (SGLT2) inhibitor.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 diabetes
What the trial is testing?
Could I receive a Placebo?
Enrollment Goal
Trial Dates
Mar 15, 2024 - Oct 2026
How long will I be in the trial?
The study will last about 14 months and may include up to 22 visits.
Trial Phase

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Be 18 years or older

  • Have a BMI of ≥ 23.0 kg/m^2

  • Have Type 2 Diabetes

  • Have high blood sugar as measured by hemoglobin A1C (HbA1c at least 7%)

  • Have impaired kidney function, an eGFR 15 to <60 mL/min/1.73 m2

  • Be taking basal Insulin

Participants Must Not:

  • Have Type 1 Diabetes

  • Have had or plan to have a surgical treatment for obesity

  • Have history of an inflamed pancreas (pancreatitis)

  • Have used any weight loss drugs within the last 3 months

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Take the Next Step

Complete this Lilly Trial Connect questionnaire to find out if this clinical trial may be a good fit for you, or a loved one.
When you press Start Lilly Trial Connect, you will answer questions about relevant medical conditions and treatment history. The answers will be compared to some of the key criteria for this trial, called inclusion and exclusion criteria.

If your responses show that the trial may be a good fit, you can:
  • Select which clinical trial site works best for you.
  • Share your details and questionnaire directly with site(s) that allow this.
  • Get contact details for the site(s) of your choice.

Completing the Trial Connect questionnaire doesn’t mean that you will be enrolled in a study. There may be more eligibility criteria for the study which are assessed by the Lilly clinical team.

Clinical Trial Resources

Diabetes Research

To learn more about diabetes and clinical trials being carried out in this area, visit our Diabetes Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.