Enrolling

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

J1I-MC-GZBO -

The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease.

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Trial Summary

Age Range
≥45 years
Conditions the trial is for
Obesity
What the trial is testing?
retatrutide
Could I receive a Placebo?
Yes
Enrollment Goal
10000
Trial Dates
Apr 30, 2024 - Feb 2029
How long will I be in the trial?
The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Must be 45 years old or older

  • Have BMI of ≥27.0 kg/m2

  • Have established ASCVD and/or CKD

Participants Must Not:

  • Have Type 1 Diabetes

  • Have had or plan to have a surgical treatment for obesity

  • Have an eGFR <20 mL/min/1.73 m^2 at screening

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.