Enrolling

A Study to Compare Tablets and Capsules of Orforglipron (LY3502970) in Healthy Participants Who Are Obese or Overweight

J2A-MC-GZPI -

The main purpose of this study is to see how much of orforglipron (study drug) gets into the bloodstream and how long it takes the body to get rid of it when given as capsules compared to tablets in healthy overweight and obese participants. The safety and tolerability (side effects) of orforglipron when given as capsules and tablets will also be evaluated.

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Trial Summary

Age Range
18 - 65 years
Conditions the trial is for
Obese, Overweight
What the trial is testing?
Orforglipron (LY3502970)
Could I receive a Placebo?
No
Enrollment Goal
508
Trial Dates
Jun 24, 2024 - May 2025
How long will I be in the trial?
The study will be conducted in two parts, with part A and B lasting up to approximately 25 and 22 weeks each respectively, including the screening period.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have a stable body weight for one month prior to study start

  • Have body mass index (BMI) of 27 to 40 kilograms per meter squared (kg/m²)

  • Have venous access sufficient to allow for blood sampling

Participants Must Not:

  • Have high blood sugar as measured by hemoglobin A1C (HbA1c) level of 6.5 percent (%) or greater

  • Have history of or currently have heart, kidney or liver disease

  • Have significant history of or currently have major depressive disorder or psychiatric disorder within the last 2 years

  • Have history of pancreatitis

  • Have or are planning a surgical treatment for excess weight

  • Have any lifetime history of a suicide attempt

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Clinical Trial Resources

Weight Management Research

To learn more about obesity, overweight and ongoing clinical trials in the area, visit our Weight Management Research page. 

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.