Enrolling

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (NEXUS-01)

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The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer.

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Trial Summary

Age Range
≥18 years
Conditions the trial is for
Solid tumors
What the trial is testing?
LY4052031
Could I receive a Placebo?
No
Enrollment Goal
220
Trial Dates
Jul 1, 2024 - May 2027
How long will I be in the trial?
The study will last up to approximately 4 years.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have one of the following solid tumor cancers: Urothelial cancer, triple negative breast cancer, non-small cell lung cancer, esophageal cancer, pancreatic cancer, ovarian cancer, cervical cancer (squamous cell cancer), head and neck squamous cell cancer or prostate cancer

  • Have stopped all cancer treatment and have recovered from the major side effects

  • Have blood test results that show that organs are working adequately

Participants Must Not:

  • Have cancer that spread to the brain and is causing symptoms

  • Have uncontrolled increase in serum calcium levels

  • Have serious disorder of the eye

  • Have serious heart condition, or lung disease

  • Have serious skin toxicity when receiving enfortumab vedotin

  • Be pregnant, breastfeeding or plan to breastfeed during study or within 30 days of last dose of study intervention

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Clinical Trial Information

A clinical trial helps us learn if a new potential medicine or treatment works and how it works. Clinical trials are also called clinical research studies. To learn more about what to expect when taking part in a clinical trial, visit our Clinical Trial Information page.