The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin).
Have high lipoprotein(a) level, at least 175 nmol/L, and either:
Be at least 18 years old and have had a cardiac event (like a heart attack or cardiac bypass surgery), a stroke, or peripheral arterial event (like a stent in an artery in the leg or an amputation)
Or
Be at least 55 years old and have risk factors for a cardiac event, like narrowing of the coronary or carotid arteries; a condition called familial hypercholesterolemia; or a group of other risk factors for cardiovascular disease
Have had major surgery, cardiac event, or stroke within 90 days of day 1
Have very high blood pressure
Have kidney failure that requires dialysis
Have chronic liver problems
Have cancer
By volunteering to take part in Cardiovascular clinical trials, you may be able to play an important role in the research and development of potential new treatments and medicines. We understand that when you or a loved one take part in a clinical trial, it is a big decision. It is important for you to understand why the research is being carried out and what taking part will mean for you. Learn more about Lilly
Cardiovascular Research
A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.